|
KMID : 0859320100280010023
|
|
Journal of the Korean Society for Therapeutic Radiology and Oncology
2010 Volume.28 No. 1 p.23 ~ p.31
|
|
|
Probabilities of Pulmonary and Cardiac Complications and Radiographic Parameters in Breast Cancer Radiotherapy
|
|
Noh Oh-Kyu
Park Sung-Ho
Ahn Seung-Do
Choi Eun-Kyung
Lee Sang-Wook
Song Si-Yeol
Yoon Sang-Min
Kim Jong-Hoon
|
|
|
Abstract
|
|
|
Purpose: To evaluate the relationship between the normal tissue complication probability (NTCP) of 3- dimensional (3-D) radiotherapy and the radiographic parameters of 2-dimensional (2-D) radiotherapy such as central lung distance (CLD) and maximal heart distance (MHD).
Materials and Methods: We analyzed 110 patients who were treated with postoperative radiotherapy for breast cancer. A two-field tangential technique, a three-field technique, and the reverse hockey stick method were used. The radiation dose administered to whole breast or the chest wall was 50.4 Gy, whereas a 45 Gy was administered to the supraclavicular field. The NTCPs of the heart and lung were calculated by the modified Lyman model and the relative seriality model.
Results: For all patients, the NTCPs of radiation-induced pneumonitis and cardiac mortality were 0.5% and 0.7%, respectively. The NTCP of radiation-induced pneumonitis was higher in patients treated with the reverse hockey stick method than in those treated by other two techniques (0.0%, 0.0%, 3.1%, p<0.001). The NTCP of radiation-induced pneumonitis increased with CLD. The NTCP of cardiac mortality increased with MHD (R2=0.808).
Conclusion: We found a close correlation between the NTCP of 3-D radiotherapy and 2-D radiographic parameters. Our results are useful to reanalyze the previous 2-D based clinical reports about breast radiation therapy complications as a viewpoint of NTCP.
|
|
|
KEYWORD
|
|
|
NTCP, Breast cancer radiotherapy, Radiographic parameter, Radiation pneumonitis, Cardiac toxicity
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|